Independent Epileptiform Discharge Patterns in the Olfactory and Limbic Areas of the in 2 Vitro Isolated Guinea Pig Brain during 4-aminopyridine Treatment
نویسندگان
چکیده
INDEPENDENT EPILEPTIFORM DISCHARGE PATTERNS IN THE OLFACTORY AND LIMBIC AREAS OF THE IN 2 VITRO ISOLATED GUINEA PIG BRAIN DURING 4-AMINOPYRIDINE TREATMENT 3 4 Giovanni Carriero, Laura Uva, Vadym Gnatkovsky, Massimo Avoli and Marco de 5 Curtis 6 7 Unit of Experimental Neurophysiology and Epileptology, Fondazione Istituto Neurologico C. 8 Besta, via Celoria 11, 20133 Milano, Italy; Montreal Neurological Institute and Departments of 9 Neurology & Neurosurgery and of Physiology, McGill University, 3801 University St., Montréal, 10 H3A 2B4, Québec, Canada; Dipartimento di Medicina Sperimentale, La Sapienza Università di 11 Roma, piazzale A. Moro 2, 00100 Roma, Italy. 12 13 GC and LU equally contributed to the present work. 14 15 The manuscript contains 20 text pages, 8 figures and no tables. 16 Running title: epileptiform discharges in olfactory-limbic cortex 17 18 Abbreviations: 4AP=4 aminopyridine; CA1=cornu ammonis area 1; CNQX= 6-cyano-719 nitroquinoxaline-2,3-dione; DNQX=6,7-dinitroquinoxaline-2,3-dione; AP5 =2-amino-520 phosphonopentanoic acid; EC=entorhinal cortex; FRs=fast runs; LOT=lateral olfactory tract; 21 PC=piriform cortex. 22 23 Address for correspondence: Marco de Curtis, Unit of Exp. Neurophysiology and Epileptology, 24 Fondazione Istituto Neurologico Carlo Besta, via Celoria 11, 20133 Milano, Italy. Tel 25 +390223942280; e-mail [email protected] 26 Formatted: Numbering: Continuous Articles in PresS. J Neurophysiol (March 10, 2010). doi:10.1152/jn.00862.2009
منابع مشابه
Independent epileptiform discharge patterns in the olfactory and limbic areas of the in vitro isolated Guinea pig brain during 4-aminopyridine treatment.
In vitro studies performed on brain slices demonstrate that the potassium channel blocker 4-aminopyridine (4AP, 50 microM) discloses electrographic seizure activity and interictal discharges. These epileptiform patterns have been further analyzed here in a isolated whole guinea pig brain in vitro by using field potential recordings in olfactory and limbic structures. In 8 of 13 experiments runs...
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